Journal of Cranio-Maxillo-Facial Surgery
Volume 38, Issue 8 , Pages 565-570 , December 2010

3D powder printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects

  • Uwe Klammert

      Affiliations

    • Department of Cranio-Maxillo-Facial Surgery (Head: Prof. Dr. Dr. Alexander C. Kübler), University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
    • Corresponding Author InformationUwe KLAMMERT, University of Würzburg, Department of Cranio-Maxillo-Facial Surgery, Pleicherwall 2, 97070 Würzburg, Germany. Tel.: +49 931 201 74845
    • ,
  • Uwe Gbureck

      Affiliations

    • Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
    • ,
  • Elke Vorndran

      Affiliations

    • Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
    • ,
  • Jan Rödiger

      Affiliations

    • Department of Cranio-Maxillo-Facial Surgery (Head: Prof. Dr. Dr. Alexander C. Kübler), University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
    • ,
  • Philipp Meyer-Marcotty

      Affiliations

    • Department of Orthodontics (Head: Prof. Dr. Angelika Stellzig-Eisenhauer), University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany
    • ,
  • Alexander C. Kübler

      Affiliations

    • Department of Cranio-Maxillo-Facial Surgery (Head: Prof. Dr. Dr. Alexander C. Kübler), University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany

Received 8 July 2009 ,Accepted 26 January 2010.

References 

  1. Bohner M, Gbureck U, Barralet JE. Technological issues for the development of more efficient calcium phosphate bone cements: a critical assessment. Biomaterials. 2005;26:6423–6429
  2. Cabanela ME, Coventry MB, MacCarty CS, Miller WE. The fate of patients with methyl methacrylate cranioplasty. J Bone Joint Surg Am. 1972;54:278–281
  3. Eufinger H, Wehmöller M, Machtens E, Heuser L, Harders A, Kruse D. Reconstruction of craniofacial bone defects with individual alloplastic implants based on CAD/CAM-manipulated CT-data. J Craniomaxillofac Surg. 1995;23:175–181
  4. Eufinger H, Wittkampf ARM, Wehmöller M, Zonneveld FW. Single-step fronto-orbital resection and reconstruction with individual resection template and corresponding titanium implant: a new method of computer-aided surgery. J Craniomaxillofac Surg. 1998;26:373–378
  5. Eufinger H, Wehmöller M, Müller C, Falk A, Machtens E. Pure titanium as bone substitute. Geometric and substance-specific aspects of computer-assisted fabrication and follow-up imaging, Mund Kiefer Gesichtschir. 2000;4(Suppl 2):504–508
  6. Eufinger H, Rasche C, Lehmbrock J, Wehmöller M, Weihe S, Schmitz I, et al. Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplasty. Biomaterials. 2007;28:475–485
  7. Gbureck U, Hölzel T, Klammert U, Würzler K, Müller FA, Barralet JE. Resorbable dicalcium phosphate bone substitutes made by 3D powder printing. Adv Funct Mater. 2007;17:3940–3945
  8. Gbureck U, Hölzel T, Doillon C, Müller FA, Barralet JE. Direct printing of bioceramic implants with spatially localised angiogenic factors. Adv Mater. 2007;19:795–800
  9. Klammert U, Reuther T, Jahn C, Kraski B, Kübler AC, Gbureck U. Cytocompatibility of brushite and monetite cell culture scaffolds made by three-dimensional powder printing. Acta Biomater. 2009;102:1120–1127
  10. Klammert U, Böhm H, Schweitzer T, Würzler K, Gbureck U, Reuther J, et al. Multi-directional Le Fort III midfacial distraction using an individual prefabricated device. J Craniomaxillofac Surg. 2009;37:210–215
  11. Kübler N, Reuther J, Kirchner T, Priessnitz B, Sebald W. Osteoinductive, morphologic, and biomechanical properties of autolyzed, antigen-extracted, allogeneic human bone. J Oral Maxillofac Surg. 1993;51:1346–1357
  12. LeGeros RZ. Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop Relat Res. 2002;395:81–98
  13. Lew D, Farrell B, Bardach J, Keller J. Repair of craniofacial defects with hydroxyapatite cement. J Oral Maxillofac Surg. 1997;55:1441–1451
  14. Marchac D, Greensmith A. Long-term experience with methylmethacrylate cranioplasty in craniofacial surgery. J Plast Reconstr Aesthet Surg. 2008;61:744–752
  15. Rohner D, Hutmacher DW, Cheng TK, Oberholzer M, Hammer B. In vivo efficacy of bone-marrow-coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig. J Biomed Mater Res B Appl Biomater. 2003;66:574–580
  16. Sawyer AA, Song SJ, Susanto E, Chuan P, Lam CXF, Woodruff MA, et al. The stimulation of healing within a rat calvarial defect by mPCL–TCP/collagen scaffolds loaded with rhBMP-2. Biomaterials. 2009;30:2479–2488
  17. Schiller C, Rasche C, Wehmöller M, Beckmann F, Eufinger H, Epple M. Geometrically structured implants for cranial reconstruction made of biodegradable polyesters and calcium phosphate/calcium carbonate. Biomaterials. 2004;25:1239–1247
  18. Scolozzi P, Martinez A, Jaques B. Complex orbito-fronto-temporal reconstruction using computer-designed PEEK implant. J Craniofac Surg. 2007;18:224–228
  19. Siebert H, Schleier P, Beinemann J, Fried W, Zenk W, Schumann D. Evaluation of individual ceramic implants made of Bioverit with CAD/CAM technology to reconstruct multidimensional craniofacial defects of the human skull, Mund Kiefer Gesichtschir. 2006;10:185–191
  20. Theiss F, Apelt D, Brand B, Kutter A, Zlinszky K, Bohner M, et al. Biocompatibility and resorption of a brushite calcium phosphate cement. Biomaterials. 2005;26:4383–4394
  21. Tschakaloff A, von Oepen R, Seibt S, Vieting M, Michaeli W. Das Begasungsverfahren zur Beladung resorbierbarer Polymere mit thermolabilen Substanzen. Dtsch Z Mund Kiefer Gesichtschir. 1996;20:47–50
  22. Weihe S, Wehmöller M, Schliephake H, Hassfeld S, Tschakaloff A, Raczkowsky J, et al. Synthesis of CAD/CAM, robotics and biomaterial implant fabrication: single-step reconstruction in computer-aided frontotemporal bone resection. Int J Oral Maxillofac Surg. 2000;29:384–388

PII: S1010-5182(10)00021-1

doi: 10.1016/j.jcms.2010.01.009

Journal of Cranio-Maxillo-Facial Surgery
Volume 38, Issue 8 , Pages 565-570 , December 2010

Article Tools

* Image Usage & Resolution