Journal of Cranio-Maxillo-Facial Surgery
Volume 39, Issue 4 , Pages 278-283 , June 2011

Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft

Received 9 December 2009 ,Accepted 23 April 2010.

References 

  1. Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study. J Oral Maxillofac Surg. 2002;60:1176–1181
  2. Aghaloo TL, Moy PK, Freymiller EG. Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study. Int J Oral Maxillofac Implants. 2004;19:59–65
  3. Aghaloo TL, Moy PK, Freymiller EG. Evaluation of platelet-rich plasma in combination with freeze-dried bone in the rabbit cranium. A pilot study. Clin Oral Implants Res. 2005;16:250–257
  4. Arpornmaeklong P, Kochel M, Depprich R, Kubler NR, Wurzler KK. Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study. Int J Oral Maxillofac Surg. 2004;33:60–70
  5. Boyne PJ, Sands NR. Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg. 1972;30:87–92
  6. Cassiede P, Dennis JE, Ma F, Caplan AI. Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-beta 1 or PDGF-BB as assayed in vivo and in vitro. J Bone Miner Res. 1996;11:1264–1273
  7. Catelas I, Sese N, Wu BM, Dunn JC, Helgerson S, Tawil B. Human mesenchymal stem cell proliferation and osteogenic differentiation in fibrin gels in vitro. Tissue Eng. 2006;12:2385–2396
  8. Choi BH, Im CJ, Huh JY, Suh JJ, Lee SH. Effect of platelet-rich plasma on bone regeneration in autogenous bone graft. Int J Oral Maxillofac Surg. 2004;33:56–59
  9. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114:1502–1508
  10. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006;118:147e–159e
  11. Frechette JP, Martineau I, Gagnon G. Platelet-rich plasmas: growth factor content and roles in wound healing. J Dent Res. 2005;84:434–439
  12. Graziani F, Ducci F, Tonelli M, El Askary AS, Monier M, Gabriele M. Maxillary sinus augmentation with platelet-rich plasma and fibrinogen cryoprecipitate: a tomographic pilot study. Implant Dent. 2005;14:63–69
  13. Harris SE, Bonewald LF, Harris MA, Sabatini M, Dallas S, Feng JQ, et al. Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res. 1994;9:855–863
  14. Hokugo A, Ozeki M, Kawakami O, Sugimoto K, Mushimoto K, Morita S, et al. Augmented bone regeneration activity of platelet-rich plasma by biodegradable gelatin hydrogel. Tissue Eng. 2005;11:1224–1233
  15. Hsieh SC, Graves DT. Pulse application of platelet-derived growth factor enhances formation of a mineralizing matrix while continuous application is inhibitory. J Cell Biochem. 1998;69:169–180
  16. Huh JY, Choi BH, Zhu SJ, Jung JH, Kim BY, Lee SH. The effect of platelet-enriched fibrin glue on bone regeneration in autogenous bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:426–431
  17. Kasperk CH, Wergedal JE, Mohan S, Long DL, Lau KH, Baylink DJ. Interactions of growth factors present in bone matrix with bone cells: effects on DNA synthesis and alkaline phosphatase. Growth Factors. 1990;3:147–158
  18. Keese E, Schmelzle R. New findings concerning early bone grafting procedures in patients with cleft lip and palate. J Craniomaxillofac Surg. 1995;23:296–301
  19. Kimura A, Ogata H, Yazawa M, Watanabe N, Mori T, Nakajima T. The effects of platelet-rich plasma on cutaneous incisional wound healing in rats. J Dermatol Sci. 2005;40:205–208
  20. Klongnoi B, Rupprecht S, Kessler P, Thorwarth M, Wiltfang J, Schlegel KA. Influence of platelet-rich plasma on a bioglass and autogenous bone in sinus augmentation. An explorative study. Clin Oral Implants Res. 2006;17:312–320
  21. Klongnoi B, Rupprecht S, Kessler P, Zimmermann R, Thorwarth M, Pongsiri S, et al. Lack of beneficial effects of platelet-rich plasma on sinus augmentation using a fluorohydroxyapatite or autogenous bone: an explorative study. J Clin Periodontol. 2006;33:500–509
  22. Le Guehennec L, Goyenvalle E, Aguado E, Pilet P, Bagot D’Arc M, Bilban M, et al. MBCP biphasic calcium phosphate granules and tissucol fibrin sealant in rabbit femoral defects: the effect of fibrin on bone ingrowth. J Mater Sci Mater Med. 2005;16:29–35
  23. Lieb E, Vogel T, Milz S, Dauner M, Schulz MB. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. II: Osteoblastic differentiation. Tissue Eng. 2004;10:1414–1425
  24. Long RE, Spangler BE, Yow M. Cleft width and secondary alveolar bone graft success. Cleft Palate Craniofac J. 1995;32:420–427
  25. Lu L, Yaszemski MJ, Mikos AG. TGF-beta1 release from biodegradable polymer microparticles: its effects on marrow stromal osteoblast function. J Bone Joint Surg Am. 2001;83-A(Suppl. 1):S82–S91
  26. Marden LJ, Fan RS, Pierce GF, Reddi AH, Hollinger JO. Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects. J Clin Invest. 1993;92:2897–2905
  27. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638–646
  28. Merkx MA, Fennis JP, Verhagen CM, Stoelinga PJ. Reconstruction of the mandible using preshaped 2.3 mm titanium plates, autogenous particulate cortico-cancellous bone grafts and platelet rich plasma: a report on eight patients. Int J Oral Maxillofac Surg. 2004;33:733–739
  29. Ogino Y, Ayukawa Y, Tsukiyama Y, Koyano K. The effect of platelet-rich plasma on the cellular response of rat bone marrow cells in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:302–307
  30. Opitz C, Meier B, Stoll C, Subklew D. Radiographic evaluation of the transplant bone height in patients with clefts of the lip/alveolus/palate after secondary bone grafting. J Orofac Orthop. 1999;60:383–391
  31. Petrungaro P. Platelet-rich plasma for dental implants and soft-tissue grafting. Interview by Arun K. Garg. Dent Implantol Update. 2001;12:41–46
  32. Petrungaro PS. Using platelet-rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery. Compend Contin Educ Dent. 2001;22:729–732
  33. Plachokova AS, van den Dolder J, Stoelinga PJ, Jansen JA. The bone regenerative effect of platelet-rich plasma in combination with an osteoconductive material in rat cranial defects. Clin Oral Implants Res. 2006;17:305–311
  34. Pryor ME, Polimeni G, Koo KT, Hartman MJ, Gross H, April M, et al. Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: histologic and histometric observations. J Clin Periodontol. 2005;32:966–972
  35. Pryor ME, Yang J, Polimeni G, Koo KT, Hartman MJ, Gross H, et al. Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: radiographic observations. J Periodontol. 2005;76:1287–1292
  36. Raghoebar GM, Schortinghuis J, Liem RS, Ruben JL, van der Wal JE, Vissink A. Does platelet-rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor?. Clin Oral Implants Res. 2005;16:349–356
  37. Rendu F, Brohard-Bohn B. The platelet release reaction: granules constituents, secretion and functions. Platelets. 2001;12:261–273
  38. Sarkar MR, Augat P, Shefelbine SJ, Schorlemmer S, Huber-Lang M, Claes L, et al. Bone formation in a long bone defect model using a platelet-rich plasma-loaded collagen scaffold. Biomaterials. 2006;27:1817–1823
  39. Schendel SA. Secondary cleft surgery. Oral Maxillofac Surg. 1994;3:1
  40. Schlegel KA, Donath K, Rupprecht S, Falk S, Zimmermann R, Felszeghy E, et al. De novo bone formation using bovine collagen and platelet-rich plasma. Biomaterials. 2004;25:5387–5393
  41. Segura-Castillo JL, Aguirre-Camacho H, Gonzalez-Ojeda A, Michel-Perez J. Reduction of bone resorption by the application of fibrin glue in the reconstruction of the alveolar cleft. J Craniofac Surg. 2005;16:105–112
  42. Slater M, Patava J, Kingham K, Mason RS. Involvement of platelets in stimulating osteogenic activity. J Orthop Res. 1995;13:655–663
  43. Soffer E, Ouhayoun JP, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:521–528
  44. Soffer E, Ouhayoun JP, Dosquet C, Meunier A, Anagnostou F. Effects of platelet lysates on select bone cell functions. Clin Oral Implants Res. 2004;15:581–588
  45. Tajima N, Sotome S, Marukawa E, Omura K, Shinomiya K. A three-dimensional cell-loading system using autologous plasma loaded into a porous β-tricalcium-phosphate block promotes bone formation at extraskeletal sites in rats. Mater Sci Eng C. 2007;27:625–632
  46. Thorwarth M, Wehrhan F, Schultze-Mosgau S, Wiltfang J, Schlegel KA. PRP modulates expression of bone matrix proteins in vivo without long-term effects on bone formation. Bone. 2006;38:30–40
  47. Wiltfang J, Kloss FR, Kessler P, Nkenke E, Schultze-Mosgau S, Zimmermann R, et al. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment. Clin Oral Implants Res. 2004;15:187–193
  48. Wiltfang J, Schlegel KA, Schultze-Mosgau S, Nkenke E, Zimmermann R, Kessler P. Sinus floor augmentation with beta-tricalciumphosphate (beta-TCP): does platelet-rich plasma promote its osseous integration and degradation?. Clin Oral Implants Res. 2003;14:213–218
  49. Witsenburg B. The reconstruction of anterior residual bone defects in patients with cleft lip, alveolus, and palate. A review. J Maxillofac Surg. 1985;13:197–208

PII: S1010-5182(10)00107-1

doi: 10.1016/j.jcms.2010.04.017

Journal of Cranio-Maxillo-Facial Surgery
Volume 39, Issue 4 , Pages 278-283 , June 2011

Article Tools

* Image Usage & Resolution